New aspect of renal phosphate reabsorption: the type IIc sodium-dependent phosphate transporter.

@article{Miyamoto2007NewAO,
  title={New aspect of renal phosphate reabsorption: the type IIc sodium-dependent phosphate transporter.},
  author={Ken-Ichi Miyamoto and Mikiko Ito and Sawako Tatsumi and Masashi Kuwahata and Hiroko Segawa},
  journal={American journal of nephrology},
  year={2007},
  volume={27 5},
  pages={
          503-15
        }
}
Abnormalities of the inorganic phosphate (Pi) reabsorption in the kidney result in various metabolic disorders. Na+-dependent Pi (Na/Pi) transporters in the brush border membrane of proximal tubular cells mediate the rate-limiting step in the overall Pi-reabsorptive process. Type IIa and type IIc Na/Pi cotransporters are expressed in the apical membrane of proximal tubular cells and mediate Na/Pi cotransport; the extent of Pi reabsorption in the proximal tubules is determined largely by the… CONTINUE READING
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