New approaches to the analysis of palindromic sequences from the human genome: evolution and polymorphism of an intronic site at the NF1 locus

@article{Lewis2005NewAT,
  title={New approaches to the analysis of palindromic sequences from the human genome: evolution and polymorphism of an intronic site at the NF1 locus},
  author={Susanna M. Lewis and Shuang Xiu Chen and Jeffrey N. Strathern and Alison J. Rattray},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={e186 - e186}
}
The nature of any long palindrome that might exist in the human genome is obscured by the instability of such sequences once cloned in Escherichia coli. We describe and validate a practical alternative to the analysis of naturally-occurring palindromes based upon cloning and propagation in Saccharomyces cerevisiae. With this approach we have investigated an intronic sequence in the human Neurofibromatosis 1 (NF1) locus that is represented by multiple conflicting versions in GenBank. We find… CONTINUE READING

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