New approaches to in-cell detection of protein activity: genetically encoded chemiluminescence probes pave the way to robust HTS assays.

Abstract

New genetically encoded biosensors utilizing the modified firefly luciferase promise a great improvement in the signal-to-noise ratio and the dynamic range of response in living cells. These biosensors are particularly suitable for high-throughput screening assays that use large-well-capacity formats because of their excellent response characteristics. The… (More)
DOI: 10.1021/cb800136v

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