New approaches for dissecting protease functions to improve probe development and drug discovery

@article{Deu2012NewAF,
  title={New approaches for dissecting protease functions to improve probe development and drug discovery},
  author={Edgar Deu and Martijn Verdoes and Matthew S Bogyo},
  journal={Nature Structural &Molecular Biology},
  year={2012},
  volume={19},
  pages={9-16}
}
Proteases are well-established targets for pharmaceutical development because of their known enzymatic mechanism and their regulatory roles in many pathologies. However, many potent clinical lead compounds have been unsuccessful either because of a lack of specificity or because of our limited understanding of the biological roles of the targeted protease. In order to successfully develop protease inhibitors as drugs, it is necessary to understand protease functions and to expand the platform… CONTINUE READING
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