• Medicine
  • Published in
    Allergologia et…
    1990

New approach to the mechanism of antiasthmatic action of Tranilast.

@article{Mesa1990NewAT,
  title={New approach to the mechanism of antiasthmatic action of Tranilast.},
  author={Milagros Garcia Mesa},
  journal={Allergologia et immunopathologia},
  year={1990},
  volume={18 1},
  pages={
          53-6
        }
}
The mechanism proposed to explain the antiasthmatic antiallergic action of Tranilast is the inhibition of chemical mediator release from mast cells and leukocytes as well as the antagonism of smooth muscle contracting activity of leukotrienes. It has been shown that this drug inhibits platelet aggregation induced "in vitro" by different stimuli. We investigated the effect of Tranilast on the release of thromboxane from guinea pig isolated lungs stimulated by the calcium ionophore A 23187 and… CONTINUE READING