New approach to antifolate treatment of certain cancers as demonstrated in tissue culture.

@article{Halpern1975NewAT,
  title={New approach to antifolate treatment of certain cancers as demonstrated in tissue culture.},
  author={R. Halpern and B. Halpern and B. Clark and H. Ashe and D. Hardy and P. Y. Jenkinson and S. C. Chou and R. Smith},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1975},
  volume={72 10},
  pages={
          4018-22
        }
}
  • R. Halpern, B. Halpern, +5 authors R. Smith
  • Published 1975
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • The selective toxicity of antifolates for a variety of cancers can be improved, as illustrated by the combined administration of N5-methyltetrahydrofolate and methotrexate in tissue culture. When a variety of neoplastic cell types characterized by a deficiency of vitamin B12-dependent N5-methyltetrahydrofolate methyltransferase (5-methyltetrahydropteroyl-L-glutamate:L-homocysteine S-methyltransferase, EC 2.1.1.13) and normal adult cells are grown in media containing methotrexate and either N5… CONTINUE READING
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