New antitumor-active azole-bridged dinuclear platinum(II) complexes: synthesis, characterization, crystal structures, and cytotoxic studies.

@article{Komeda2000NewAA,
  title={New antitumor-active azole-bridged dinuclear platinum(II) complexes: synthesis, characterization, crystal structures, and cytotoxic studies.},
  author={Seiji Komeda and Martin Lutz and Anthony L. Spek and Masahiko Chikuma and Jan Reedijk},
  journal={Inorganic chemistry},
  year={2000},
  volume={39 19},
  pages={4230-6}
}
Three new derivatives of the cytotoxic azole-bridged dinuclear platinum(II) complex [(cis-Pt(NH3)2)2(mu-OH)(mu-pz)][NO3]2 (1) have been prepared and structurally characterized. Their formulas are [(cis-Pt(NH3)2)2(mu-OH)(mu-1,2,3-ta)][NO3]2 (2) (1,2,3-ta = 1,2,3-triazolate), [(Pt(R,R-dach))(mu-OH)(mu-pz)(Pt(S,S- dach))][NO3]2 (3) (dach = 1,2-diaminocyclohexane, pz = pyrazolate), and [(Pt(R,R-dach))(mu-1,2,3- ta)2(Pt(S,S-dach))][NO3]2 (4). The compounds were characterized by 1H, 13C, and 195Pt… CONTINUE READING

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