New antituberculotics originated from salicylanilides with promising in vitro activity against atypical mycobacterial strains.

@article{Imramovsk2009NewAO,
  title={New antituberculotics originated from salicylanilides with promising in vitro activity against atypical mycobacterial strains.},
  author={Ale{\vs} Imramovsk{\'y} and Jarmila Vin{\vs}ov{\'a} and Juana Monreal F{\'e}rriz and Rafael Dolezal and Josef Jamp{\'i}lek and Jarmila Kaustov{\'a} and Filip Kun{\vc}},
  journal={Bioorganic & medicinal chemistry},
  year={2009},
  volume={17 10},
  pages={3572-9}
}
A new series of 30 N-protected amino acid esters were prepared as a part of ongoing search for new anti-tuberculosis active salicylanilides. The esters possess high in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium, and two strains of Mycobacterium kansasii, where one is an isolate from the patient, with MIC in the range 1-32 micromol/L for all tested strains. The prepared esters can be considered as prodrugs with better bio-availability and as more efficient transport… CONTINUE READING
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