New antimicrobial agents for Gram-positive infections.


Increasing antimicrobial resistance in Gram-positive bacteria has presented a formidable treatment problem. The enterococci, although traditionally non-virulent pathogens, have been shown, when associated with vancomycin resistance, to have an attributable mortality of approximately 40%. The frightening specter of widespread vancomycin resistance in the more virulent Staphylococcus aureus would have a significantly greater impact. Since the late 1980s, advances have been made in the development of pharmacological weapons against multiply resistant Gram-positive bacterial infections. At least seven new antimicrobial classes that have activity against resistant Gram-positive organisms are in various stages of development. Most are semisynthetic derivatives of known antibiotics; however, importantly, a unique class of antimicrobial agent has also emerged.

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@article{Brooks1998NewAA, title={New antimicrobial agents for Gram-positive infections.}, author={Ann K Brooks and Marcos J Zervos}, journal={Current opinion in infectious diseases}, year={1998}, volume={11 6}, pages={667-71} }