New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analogues.

@article{Kasai2001NewAH,
  title={New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analogues.},
  author={S. Kasai and H. Nagasawa and M. Yamashita and M. Masui and H. Kuwasaka and T. Oshodani and Y. Uto and T. Inomata and S. Oka and S. Inayama and H. Hori},
  journal={Bioorganic \& medicinal chemistry},
  year={2001},
  volume={9 2},
  pages={
          453-64
        }
}
We designed, based on the molecular orbital (MO) calculation, synthesized, and evaluated the biological activities of the new antimetastatic hypoxic cell radiosensitizer, 2-nitroimidazole-acetamide, TX-1877, and its analogues. Each analogue has an electron-affinic imidazole group, an acetamide group and a certain hydrophilic group to control its biological effect, toxicity, and pharmacokinetics. In in vitro radiosensitization assay, most TX-1877 analogues, which have an electron affinity (EA… Expand
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References

SHOWING 1-10 OF 23 REFERENCES
TX-1877: design, synthesis, and biological activities as a BRM-functional hypoxic cell radiosensitizer.
KIH-802: 2-nitroimidazole-1-acetohydroxamate as a hypoxic cell radiosensitizer.
Lung metastasis suppression of the bifunctional new radiosensitizer KIN-806.
Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice.
...
1
2
3
...