New antiepileptic drugs
@article{Harden1994NewAD, title={New antiepileptic drugs}, author={Cynthia Harden}, journal={Neurology}, year={1994}, volume={44}, pages={787 - 787} }
Antiepileptic drugs (AEDs) were first developed by empiric drug testing, without any basic understanding of epileptic processes. Bromide salts were used for epilepsy in the last century with the notion that this medicine would suppress sexual desire, which-according t o prevailing scientific thought in the 1860s-would in turn suppress seizure activity.l However, the sedative action of bromides correlated with seizure reduction, which led to the discovery in 1912 of another sedative with…
37 Citations
Low propensity of conventional antiepileptic drugs for interaction with felbamate against maximal electroshock-induced seizures in mice
- Psychology, BiologyJournal of Neural Transmission
- 2017
The results indicate that the combination of felbamate with conventional antiepileptic drugs is not promising from the experimental point of view.
Influence of d-cycloserine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice
- Medicine, BiologyEpilepsy Research
- 2000
Psychotic disorder after lamotrigine
- Psychology, MedicineThe Italian Journal of Neurological Sciences
- 2006
Lamotrigine is an antiepileptic drug that acts mainly to inhibit excitatory-aminoacid release and hence stabilise neuronal membranes via blockade of voltage-sensitive sodium channels, and its commonest side effects are nausea, headache, diplopia, blurred vision, dizziness, ataxia, somnolence and maculo-papular rash.
Topiramate: a review of preclinical, pharmacokinetic, and clinical data.
- MedicineClinical therapeutics
- 1997
Topiramate. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of epilepsy.
- Medicine, PsychologyDrugs
- 1997
Preliminary reports support the use of add-on topiramate in adults with generalised epilepsy, in childhood epilepsies and in patients with Lennox-Gastaut syndrome, as well as theUse of topIRamate monotherapy in patientsWith refractory epilepsy,topiramate can be considered an important new drug for the management of patients with refractors.
Topiramate potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice.
- Medicine, PsychologyEuropean journal of pharmacology
- 2000
Epilepsia y embarazo
- Medicine
- 2005
Pregnancy is generally safe in the woman with epilepsy, but the preconceptional support and near support between the neurologist and the gynecologist during the pregnancy must be assured.
Antiepileptic drug treatment in the nineties in The Netherlands.
- Medicine, PsychologyPharmacy World and Science
- 2004
In this review the ‘state of the art’ of treating patients with epilepsy in the nineties in the Netherlands is presented. It describes general strategies for treatment with antiepileptic drugs and…
Repurposing drugs to treat l-DOPA-induced dyskinesia in Parkinson's disease
- BiologyNeuropharmacology
- 2019
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The irreversible GABA transaminase inhibitor vigabatrin was given in a single-blind fashion to 89 patients with complex partial seizures refractory to conventional drugs, and most patients have retained their initial favorable CPS control.
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LTG was added to existing anti‐epileptic drugs of adult patients with refractory epilepsy, using a twice‐daily regimen, and no significant changes in plasma concentrations of concomitant AEDs after the addition of LTG were observed.
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Three large studies, all including more than 60 children, on the efficacy on gamma-vinyl GABA (vigabatrin, GVG) in the treatment of childhood epilepsy have been reviewed. On the basis of these and…
Felbamate: A double‐blind controlled trial in patients undergoing presurgical evaluation of partial seizures
- Medicine, PsychologyNeurology
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The ability of felbamate to quickly and safely reduce the occurrence of frequent partial-onset seizures and maintain effective seizure control following reductions in the dosages of standard antiepileptic drugs is demonstrated.