New antiarrhythmic agents. 6. Quantitative structure-activity relationships of aminoxylidides.

@article{Tenthorey1981NewAA,
  title={New antiarrhythmic agents. 6. Quantitative structure-activity relationships of aminoxylidides.},
  author={P A Tenthorey and A J Block and Robert A. Ronfeld and P D McMaster and E W Byrnes},
  journal={Journal of medicinal chemistry},
  year={1981},
  volume={24 7},
  pages={798-806}
}
The synthesis and pharmacological evaluation of primary and tertiary aminoxylidides with the amino group in the 2-7 position of the acyl chain are described. 2,6-Xylidine was acylated with haloacyl halides and converted to the target compounds by direct amination or by the Gabriel procedure. Alternatively, 2,6-xylidine was coupled with keto acids, and the… CONTINUE READING