New antiangiogenetic agents and non-small cell lung cancer.

  title={New antiangiogenetic agents and non-small cell lung cancer.},
  author={Cesare Gridelli and Antonio Rossi and Paolo Maione},
  journal={Critical reviews in oncology/hematology},
  volume={60 1},
New blood vessel formation, known as angiogenesis is a fundamental event in the process of tumor growth and metastatic dissemination. Due to its central role in tumor angiogenesis, the vascular endothelial growth factor (VEGF) and its receptor have been a major focus of basic research and drug development in the field of oncology, including the treatment of non-small cell lung cancer (NSCLC). Approaches targeting VEGF include monoclonal antibodies and vascular endothelial growth factor receptor… CONTINUE READING