New anti-mitotic drugs with distinct anti-calmodulin activity.

@article{Orosz2006NewAD,
  title={New anti-mitotic drugs with distinct anti-calmodulin activity.},
  author={Ferene Orosz and Istv{\'a}n Horv{\'a}th and Judit Ov{\'a}di},
  journal={Mini reviews in medicinal chemistry},
  year={2006},
  volume={6 10},
  pages={1145-57}
}
Bisindole Vinca alkaloids target microtubule system causing anti-mitotic activity. The problem of their clinical application is the lack of selectivity resulting in toxic side effects. In this paper we review the late history of new bisindole derivatives focusing on KARs recognized as potent anti-cancer drugs with low side effect. KARs, just as other bisindoles, impede microtubule assembly of mitotic spindle, however, they display no anti-calmodulin activity. This new drug family appears to be… CONTINUE READING

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