New anti-mitotic drugs with distinct anti-calmodulin activity.

  title={New anti-mitotic drugs with distinct anti-calmodulin activity.},
  author={Ferene Orosz and Istv{\'a}n Horv{\'a}th and Judit Ov{\'a}di},
  journal={Mini reviews in medicinal chemistry},
  volume={6 10},
Bisindole Vinca alkaloids target microtubule system causing anti-mitotic activity. The problem of their clinical application is the lack of selectivity resulting in toxic side effects. In this paper we review the late history of new bisindole derivatives focusing on KARs recognized as potent anti-cancer drugs with low side effect. KARs, just as other bisindoles, impede microtubule assembly of mitotic spindle, however, they display no anti-calmodulin activity. This new drug family appears to be… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-5 of 5 extracted citations

Ion channels and transporters in cancer. 1. Ion channels and cell proliferation in cancer.

American journal of physiology. Cell physiology • 2011
View 10 Excerpts
Highly Influenced

Targeting the calmodulin-regulated ErbB/Grb7 signaling axis in cancer therapy.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques • 2013

Progress in the development of early diagnosis and a drug with unique pharmacology to improve cancer therapy

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…