New anti-GD2 monoclonal antibodies produced from gamma-interferon-treated neuroblastoma cells.

@article{Gro1989NewAM,
  title={New anti-GD2 monoclonal antibodies produced from gamma-interferon-treated neuroblastoma cells.},
  author={Nicole Gro\ss and Daniel R Beck and Jacques Portoukalian and Sophie Favre and Stefan Carrel},
  journal={International journal of cancer},
  year={1989},
  volume={43 4},
  pages={665-71}
}
Three monoclonal antibodies (IgG2) have been produced from hybridomas obtained by fusion of murine myeloma cells and spleen cells of mice hyperimmunized with gamma-interferon-treated neuroblastoma cells. The 3 MAbs, 7A4, 2A6 and IG8, detected an antigen present on neuroblastoma tumors and cell lines, but also on some neuro-ectoderm-derived tissues and cells. All 3 clones were shown to react with an epitope of the di-sialo-ganglioside GD2 molecules highly expressed by some neuro-ectoderm-derived… CONTINUE READING
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