New animal model for objective pain research: non- invasive functional imaging in anesthetized animals by BOLD fMRI to study initial processes of chronic pain


The experience of acute pain is an elementary sensation necessary for maintaining individual integrity and well-being in interaction with the environment. However, repetitive noxious input can induce chronic pain states without any biological advantage. Long-term changes in the excitability of neurons have been shown at the peripheral and spinal cord levels… (More)


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