New angiotensin I isolated from a reptile, Alligator mississippiensis.

  title={New angiotensin I isolated from a reptile, Alligator mississippiensis.},
  author={Yoshiyuki Takei and E P Silldorff and Yoshihisa Hasegawa and Takushi X. Watanabe and Kiichiro Nakajima and Gregory A. Stephens and Sachiko Sakakibara},
  journal={General and comparative endocrinology},
  volume={90 2},
Angiotensin I (ANG I) of the American alligator Alligator mississippiensis was isolated from incubates of homologous plasma and kidney extract, and its amino acid sequence was determined as H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-Ala-Leu-OH. The presence of strongly hydrophobic alanine at position 9 is unusual among ANGs I sequenced to date. Since alanine can be converted to serine by a one-point mutation of the triplet nucleotides, the phylogenetic proximity of the alligator to birds, whose ANG I… CONTINUE READING