New and selective ryanodine receptor activators for insect control.

  title={New and selective ryanodine receptor activators for insect control.},
  author={George P. Lahm and Daniel Andr{\'e}s C{\'o}rdova and James D Barry},
  journal={Bioorganic & medicinal chemistry},
  volume={17 12},
Diamide insecticides have emerged as one of the most promising new classes of insecticide chemistry owing to their excellent insecticidal efficacy and high margins of mammalian safety. Chlorantraniliprole and flubendiamide, the first two insecticides from this class, demonstrate exceptional activity across a broad range of pests in the order Lepidoptera. This chemistry has been confirmed to control insects via activation of ryanodine receptors which leads to uncontrolled calcium release in… CONTINUE READING

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