New and Emerging Radiosensitizers and Radioprotectors

@article{Spalding2006NewAE,
  title={New and Emerging Radiosensitizers and Radioprotectors},
  author={Aaron C. Spalding and Theodore S. Lawrence},
  journal={Cancer Investigation},
  year={2006},
  volume={24},
  pages={444 - 456}
}
The combination of chemotherapy and radiation has led to clinical breakthroughs in several disease sites, and current work continues to define optimum combinations of proven chemotherapy as well as more recently available, noncytotoxic agents. Administration of systemic therapies allows modulation of radiation response to improve tumor control (radiosensitization) or to prevent normal tissue toxicity (radioprotection). Substantial progress has been made in identifying the targets of standard… 
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References

SHOWING 1-10 OF 159 REFERENCES
The mechanism of action of radiosensitization of conventional chemotherapeutic agents.
TLDR
Loss of the S-phase checkpoint in cancer cells may provide the molecular basis for selective killing of tumors compared with normal tissues, and the identification of the enzymatic targets for these drugs offers the potential to develop predictive assays for response and to develop methods of imaging the progress of therapy.
Taxol: a novel radiation sensitizer.
Evidence for a therapeutic gain when AQ4N or tirapazamine is combined with radiation.
TLDR
In the model, an increase in the therapeutic index was obtained for radiation treatment when either AQ4N or tirapazamine was administered concurrently, and this was in contrast to mitomycin C which had a marked effect on the radiation induced functional deficit.
Schedule-Dependent Pulsed Paclitaxel Radiosensitization for Thoracic Malignancy
TLDR
It is concluded that pulsed low-dose paclitaxel and radiation is a very effective and well-tolerated regimen for thoracic malignancy.
Clinical trial of endorectal amifostine for radioprotection in patients with prostate cancer: rationale and early results.
TLDR
This trial evaluates the rates of early and late rectal toxicities in patients with prostate cancer receiving definitive or adjuvant three-dimensional conformal external beam radiation therapy and concurrent daily endorectal applications of amifostine.
Combining EGFR inhibitors with radiation or chemotherapy: will preclinical studies predict clinical results?
Four decades of continuing innovation with fluorouracil: current and future approaches to fluorouracil chemoradiation therapy.
TLDR
FU chemoradiotherapy maximizes local control and, for some tumor sites, improves survival rates and the introduction of oral prodrug analogs will likely further improve the results of FU therapy in several organ systems, such as the rectum, head and neck, and esophagus.
Substitution of oral fluoropyrimidines for infusional fluorouracil with radiotherapy: how much data do we need?
  • C. Crane, D. Sargent
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2004
TLDR
Oral UFT is a good candidate for phase III study in combination with radiotherapy, as is its counterpart, capecitabine, approved in the United States for metastatic colorectal cancer when single-agent fluoropyrimidine therapy is indicated.
Taxol sensitizes human astrocytoma cells to radiation.
TLDR
The results of combined taxol-radiation exposures in the human Grade III astrocytoma cell line, G18, suggest that appropriate combinations of taxol have a more than additive interaction in human tissue culture and may have a role in clinical protocols.
Concomitant chemotherapy and radiation therapy certainly improves local control.
  • J. Cooper, K. Ang
  • Medicine
    International journal of radiation oncology, biology, physics
  • 2005
...
...