New analysis fuels debate on merits of prescribing statins to low risk people

@article{Kmietowicz2014NewAF,
  title={New analysis fuels debate on merits of prescribing statins to low risk people},
  author={Zosia Kmietowicz},
  journal={BMJ : British Medical Journal},
  year={2014},
  volume={348}
}
  • Z. Kmietowicz
  • Published 25 March 2014
  • Medicine
  • BMJ : British Medical Journal
The controversy concerning the prescribing of statins to a wider section of the population showed no signs of abating this week after a new analysis—this time of high quality observational studies involving data on millions of patients—found that the risk of harmful effects from statins was very small and similar to those seen in clinical trials.1 The finding is fuelling the debate on whether statins should be extended to healthy people who are at low risk of cardiovascular disease, as… 
3 Citations
Effect of Statins use on Cardiac, Diabetes, Kidney and Liver Function – An update
TLDR
Among the statins used, atorvastatin was found to be very beneficial with minimal side effects with greater beneficial function in maintaining other organ functions and some merits shown in the use of statins include prevention of MCI and strokes.

References

SHOWING 1-8 OF 8 REFERENCES
Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis
TLDR
High quality observational data can provide relevant evidence on unintended effects of statins to add to the evidence from RCTs, according to a systematic review and meta-analyses.
Statins may have fewer side effects than is claimed, meta-analysis finds
  • J. Wise
  • Medicine
    BMJ : British Medical Journal
  • 2014
Only a few types of side effect reported from use of statins are genuinely due to the drug itself, as almost all side effects were reported just as often with a placebo, a systematic review of
NICE recommends wider use of statins in draft guidelines
  • J. Wise
  • Medicine
    BMJ : British Medical Journal
  • 2014
TLDR
Draft guidance from the National Institute for Health and Care Excellence recommends that doctors use the QRISK2 assessment tool to identify people aged 40-74 who are likely to be at high risk of developing cardiovascular disease.
Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease
The National Institute for Health and Clinical Excellence (NICE) guideline, Lipid modification: Cardiovascular risk assessment and the modification of blood lipids for the primary and secondary
Should people at low risk of cardiovascular disease take a statin?
TLDR
It is argued that statins have no overall health benefit in this population and that prescribing guidelines should not be broadened.
Saturated fat is not the major issue
Let’s bust the myth of its role in heart disease
Doctors' fears over statins may cost lives, says top medical researcher