New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents.

@article{Ziakas2006NewAO,
  title={New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents.},
  author={George N Ziakas and Eleni A. Rekka and Antonios M Gavalas and Phaedra Th. Eleftheriou and Panos N. Kourounakis},
  journal={Bioorganic & medicinal chemistry},
  year={2006},
  volume={14 16},
  pages={5616-24}
}
Amine or amide derivatives bearing the 2,6-di-tert-butyl phenol moiety are synthesised. Almost all are antioxidants, reduce acute inflammation and inhibit COX-1 and lipoxygenase activity. The most potent anti-inflammatory, COX-1 inhibitor and antioxidant agent, with low toxicity, is 2,6-di-tert-butyl-4-thiomorpholin-4-ylmethyl-phenol. 

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