New amide and dioxopiperazine derivatives from leaves of Breynia nivosa.

@article{Umeokoli2017NewAA,
  title={New amide and dioxopiperazine derivatives from leaves of Breynia nivosa.},
  author={Blessing O. Umeokoli and Felix Ahamefule Onyegbule and Festus Basden Chiedu Okoye and Hao Wang and Rainer Kalscheuer and Werner E. G. M{\"u}ller and Rudolf Hartmann and Zhen Liu and Peter Proksch},
  journal={Fitoterapia},
  year={2017},
  volume={122},
  pages={
          16-19
        }
}

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TLDR
A new nor-ceanothane-type triterpenoid, breynceanothanolic acid, and seven novel 4α-methyl sterols, fruticosides A-G (2-8), were obtained from the roots of Breynia fruticosa by means of extensive spectroscopic and chemical methods.
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Two dipeptides, saropeptate (aurantiamide acetate) and anabellamide, were isolated from the methanol root extract of Zapoteca portoricensis and their chemical structures deduced by one dimensional and two dimensional NMR and mass spectrometry.
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The new derivative kahalalide R was found to exert comparable or even higher cytotoxicity than the potential drug candidate kahAlalide F toward the MCF7 human mammary carcinoma cell line.
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Cultivation of the fungal strain Eurotium rubrum, an endophytic fungus that was isolated from the inner tissue of stems of the mangrove plant Hibiscus tiliaceus, resulted in the isolation of two new
Structure-activity relationship of pentacylic triterpene esters from Uncaria rhynchophylla as inhibitors of phospholipase Cgamma1.
TLDR
The results indicate that 3-OH and 27-esterification may be essential, and that 28-COOH and the 2' double bond appear to be important for activity.
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Breynia nivosa is used in treating headaches, toothaches and tooth infections. This study evaluated some ethnomedicinal uses of leaves of the plant. B. nivosa leaves were extracted with ethanol, and
Antimalarial activities of Breynia Nivosa
TLDR
The extract dose-dependently reduced parasitaemia induced by chloroquine sensitive Plasmodium berghei infection in prophylactic, suppressive and curative models in mice, and these reductions were statistically significant.
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