New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.

@article{Fink1995NewAD,
  title={New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.},
  author={Cynthia A. Fink and Yali Qiao and Christopher J. Berry and Yumi Sakane and Rajendra D. Ghai and Angelo J. Trapani},
  journal={Journal of medicinal chemistry},
  year={1995},
  volume={38 26},
  pages={5023-30}
}
Dual inhibitors of the two zinc metallopeptidases, neutral endopeptidase (NEP, EC 3.4.24.11) and angiotensin-I converting enzyme, have been the focus of much clinical interest for the treatment of hypertension and congestive heart failure. A novel series of alpha-thio dipeptides containing central cyclic non-natural amino acids were prepared and were… CONTINUE READING