New alginate microcapsule system for angiogenic protein delivery and immunoisolation of islets for transplantation in the rat omentum pouch.

@article{McQuilling2011NewAM,
  title={New alginate microcapsule system for angiogenic protein delivery and immunoisolation of islets for transplantation in the rat omentum pouch.},
  author={John Patrick McQuilling and Juan Arenas-Herrera and Charles K Childers and Rajesh A. Pareta and O Khanna and B Jiang and Eric M. Brey and Alan C. Farney and Emmanuel C Opara},
  journal={Transplantation proceedings},
  year={2011},
  volume={43 9},
  pages={3262-4}
}
Severe hypoxia caused by a lack of vascular supply and an inability to retrieve encapsulated islets transplanted in the peritoneal cavity for biopsy and subsequent evaluation are obstacles to clinical application of encapsulation strategies for islet transplantation. We recently proposed an omentum pouch model as an alternative site of encapsulated islet transplantation and have also described a multi-layer microcapsule system suitable for coencapsulation of islets with angiogenic protein in… CONTINUE READING
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