New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

@inproceedings{Zhu2017NewAT,
  title={New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463},
  author={Yi Zhu and Ewald J. Doornebal and Tamar Pirtskhalava and Nino Giorgadze and Mark Wentworth and Heike Fuhrmann-Stroissnigg and Laura J. Niedernhofer and P. David Robbins and Tamara T. Tchkonia and James l. Kirkland},
  booktitle={Aging},
  year={2017}
}
Senescent cells accumulate with aging and at sites of pathology in multiple chronic diseases. Senolytics are drugs that selectively promote apoptosis of senescent cells by temporarily disabling the pro-survival pathways that enable senescent cells to resist the pro-apoptotic, pro-inflammatory factors that they themselves secrete. Reducing senescent cell burden by genetic approaches or by administering senolytics delays or alleviates multiple age- and disease-related adverse phenotypes in… CONTINUE READING
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