New advances in the understanding of the pathophysiology of chronic venous insufficiency.

@article{SchmidSchnbein2001NewAI,
  title={New advances in the understanding of the pathophysiology of chronic venous insufficiency.},
  author={Geert W Schmid-Sch{\"o}nbein and Shinya Takase and John J. Bergan},
  journal={Angiology},
  year={2001},
  volume={52 Suppl 1},
  pages={S27-34}
}
Chronic venous insufficiency (CVI) is inseparably linked to elevated venous pressure and is accompanied by vascular, dermal, and subcutaneous tissue damage and restructuring. Abundant evidence exists both in humans and in experimental models to suggest that the tissue damage may be initiated by generation of an inflammatory reaction. Inflammatory indicators include elevation of endothelial permeability; attachment of circulating leukocytes to the endothelium; infiltration of monocytes… CONTINUE READING

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