New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine
@article{Orsolini2016NewAI, title={New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine}, author={Laura Orsolini and Carmine Tomasetti and Alessandro Valchera and Felice Iasevoli and Elisabetta Filomena Buonaguro and Federica Vellante and Michele Fornaro and Annastasia L C Fiengo and Monica Mazza and Roberta Vecchiotti and Giampaolo Robert Perna and Andrea de Bartolomeis and Giovanni Martinotti and Massimo Di Giannantonio and Domenico de Berardis}, journal={Expert Review of Neurotherapeutics}, year={2016}, volume={16}, pages={483 - 495} }
Generalized Anxiety Disorder (GAD) is a persistent condition characterized by chronic anxiety, exaggerated worry and tension, mainly comorbid with Major Depressive Disorder (MDD. [] Key Result Only two studies, of which one prevention relapse trial, reported a significant improvement in anxiety symptomatology compared to three with negative findings.
16 Citations
Pharmacotherapy for generalized anxiety disorder in adult and pediatric patients: an evidence-based treatment review
- Medicine, PsychologyExpert opinion on pharmacotherapy
- 2018
An algorithmic approach to the pediatric and adult patient with GAD is described and considerations for the use of selected medications in these patients are highlighted.
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Adjunctive vortioxetine for SSRI-resistant major depressive disorder: a “real-world” chart review study
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Adjunctive vortioxetine may be useful and well-tolerated in stage I treatment-resistant depression, and the limitations of this study (such as small sample size, absence of randomization and control group, retrospective design, etc.) must be considered.
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An open-label, flexible dose adaptive study evaluating the efficacy of vortioxetine in subjects with panic disorder
- Psychology, MedicineAnnals of General Psychiatry
- 2018
Some support for the use of vortioxetine in the management of panic disorder is provided, with a statistically significant decrease in the occurrence of panic attacks and a moderate improvement in the quality of life.
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Relative short‐term efficacy and acceptability of agomelatine versus vortioxetine in adult patients suffering from major depressive disorder
- Psychology, MedicineHuman psychopharmacology
- 2018
An adjusted indirect comparison using placebo as a common control found no difference in efficacy or acceptability of agomelatine compared to vortioxetine in adult patients with major depressive disorder.
Can Long-Term Pharmacotherapy Prevent Relapses in Generalized Anxiety Disorder? A Systematic Review
- Psychology, MedicineClinical Drug Investigation
- 2017
Long-term pharmacotherapy may prevent symptom relapse in GAD patients and as the relapse rate is very high, the data support the continuation of pharmacotherapy for as long as possible.
Preclinical characterization of ACH-000029, a novel anxiolytic compound acting on serotonergic and alpha-adrenergic receptors
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