New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vector-mediated strategy.

@article{Rousselle2000NewAI,
  title={New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vector-mediated strategy.},
  author={Christophe Rousselle and Pascal Clair and J. M. Lefauconnier and Michel Kaczorek and J. M. Scherrmann and J. Temsamani},
  journal={Molecular pharmacology},
  year={2000},
  volume={57 4},
  pages={679-86}
}
Many therapeutic drugs are excluded from entering the brain, due to their lack of transport through the blood-brain barrier (BBB). To overcome this problem, we have developed a novel method in which short, naturally derived peptides (16-18 amino acids) cross the cellular membranes of the BBB with high efficiency and without compromising its integrity. The antineoplastic agent doxorubicin (dox) was coupled covalently to two peptides, D-penetratin and SynB1. The ability of dox to cross the BBB… CONTINUE READING

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