New activated RAS2 mutations identified in Saccharomyces cerevisiae.

  title={New activated RAS2 mutations identified in Saccharomyces cerevisiae.},
  author={Brenda A. Wilson and M Khalil and Fuyuhiko Tamanoi and John F. Cannon},
  volume={8 12},
Activating mutations in RAS proto-oncogenes encode proteins with greater GTP binding. Such mutant proteins are responsible for many human cancers. Six new amino acids were discovered that can yield an activated Saccharomyces cerevisiae RAS2 protein when they are altered. These new RAS2 alleles were found among a collection of 35 random mutations that exhibit a dominant reduction of glycogen accumulation. The RAS2-P41S and RAS2-E99K alleles encode proteins that have lost responsiveness to GTPase… CONTINUE READING