New Twists in Gene Regulation by Glucocorticoid Receptor: Is DNA Binding Dispensable?

  title={New Twists in Gene Regulation by Glucocorticoid Receptor: Is DNA Binding Dispensable?},
  author={Michael Karin},
effect on cooperative binding to palindromic GREs, but do not completely abolish DNA binding (Dahlman-Wright et al., 1991). The view of GR as a ligand-regulated transcription factor that accomplishes all of its physiological func-sion of genes that contain such elements, however, lasted only until 1990. Although it was realized that GC can also repress the expression of certain genes, most Discovered in the 1930s in adrenal gland extracts, gluco-of the attention until that time has focused on… CONTINUE READING
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