New Twists in Gene Regulation by Glucocorticoid Receptor: Is DNA Binding Dispensable?

@article{Karin1998NewTI,
  title={New Twists in Gene Regulation by Glucocorticoid Receptor: Is DNA Binding Dispensable?},
  author={Michael Karin},
  journal={Cell},
  year={1998},
  volume={93},
  pages={487-490}
}
effect on cooperative binding to palindromic GREs, but do not completely abolish DNA binding (Dahlman-Wright et al., 1991). The view of GR as a ligand-regulated transcription factor that accomplishes all of its physiological func-sion of genes that contain such elements, however, lasted only until 1990. Although it was realized that GC can also repress the expression of certain genes, most Discovered in the 1930s in adrenal gland extracts, gluco-of the attention until that time has focused on… CONTINUE READING
Highly Cited
This paper has 145 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 74 extracted citations

The emerging role of C/EBPs in glucocorticoid signaling: lessons from the lung.

The Journal of endocrinology • 2012
View 11 Excerpts
Highly Influenced

Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats.

Drug metabolism and disposition: the biological fate of chemicals • 2000
View 12 Excerpts
Highly Influenced

146 Citations

01020'98'03'09'15
Citations per Year
Semantic Scholar estimates that this publication has 146 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 19 references

Annu. Rev. Genet

K R Yamamoto
Annu. Rev. Genet • 1985
View 3 Excerpts
Highly Influenced

Cell

H M Reichardt, K H Kaestner, J Tuckermann
Cell • 1998

BioEssays

M Meister, B Lemaitre, J A Hoffmann
BioEssays • 1997
View 1 Excerpt

N. Engl. J. Med

P J Barnes, Karin
N. Engl. J. Med • 1997

Cell

Z.-G Liu, H Hu, D V Goeddel, Karin
Cell • 1996

Science

A A Beg, D Baltimore
Science • 1996
View 2 Excerpts

Cell

M Beato, P Herrlich, G Schü Tz
Cell • 1995

EMBO J

A Helmberg, N Auphan, C Caelles, Karin
EMBO J • 1995

Genes Dev

T J Cole, J A Blendy, +7 authors G Schü Tz
Genes Dev • 1995

Science

N Auphan, J A Didonato, C Rosette, A Helmberg, Karin
Science • 1995