New Techniques for the Production of Therapeutic Recombinant Human Monoclonal Antibodies

Abstract

Hybridoma technology has enabled the production of large quantities of murine monoclonal antibodies (mAbs) directed to specific antigens. However, the therapeutic usefulness of these reagents in humans has been limited by the unwanted immune response induced in patients. Although human mAbs are difficult to obtain with conventional techniques, murine mAbs… (More)
DOI: 10.1007/BF03259294

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