New Structure Sheds Light on Selective HIV-1 Genomic RNA Packaging

  title={New Structure Sheds Light on Selective HIV-1 Genomic RNA Packaging},
  author={Erik D. Olson and William A. Cantara and K. Musier-Forsyth},
  pages={4826 - 4835}
Two copies of unspliced human immunodeficiency virus (HIV)-1 genomic RNA (gRNA) are preferentially selected for packaging by the group-specific antigen (Gag) polyprotein into progeny virions as a dimer during the late stages of the viral lifecycle. Elucidating the RNA features responsible for selective recognition of the full-length gRNA in the presence of an abundance of other cellular RNAs and spliced viral RNAs remains an area of intense research. The recent nuclear magnetic resonance (NMR… Expand
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