New Sipanmycin Analogues Generated by Combinatorial Biosynthesis and Mutasynthesis Approaches Relying on the Substrate Flexibility of Key Enzymes in the Biosynthetic Pathway

@article{Malmierca2019NewSA,
  title={New Sipanmycin Analogues Generated by Combinatorial Biosynthesis and Mutasynthesis Approaches Relying on the Substrate Flexibility of Key Enzymes in the Biosynthetic Pathway},
  author={M{\'o}nica G Malmierca and Ignacio P{\'e}rez-Victoria and Jes{\'u}s Mart{\'i}n and Fernando Reyes and Carmen M{\'e}ndez and Jos{\'e} A Salas and Carlos Olano},
  journal={Applied and Environmental Microbiology},
  year={2019},
  volume={86}
}
Combinatorial biosynthesis has proved its usefulness in generating derivatives of already known compounds with novel or improved pharmacological properties. Sipanmycins are a family of glycosylated macrolactams produced by Streptomyces sp. strain CS149, whose antiproliferative activity is dependent on the sugar moieties attached to the aglycone. In this work, we report the generation of several sipanmycin analogues with different deoxysugars, showing the high degree of flexibility exerted by… 
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