New Serological Markers for Inflammatory Bowel Disease Are Associated With Earlier Age at Onset, Complicated Disease Behavior, Risk for Surgery, and NOD2/CARD15 Genotype in a Hungarian IBD Cohort

@article{Papp2008NewSM,
  title={New Serological Markers for Inflammatory Bowel Disease Are Associated With Earlier Age at Onset, Complicated Disease Behavior, Risk for Surgery, and NOD2/CARD15 Genotype in a Hungarian IBD Cohort},
  author={M{\'a}ria Papp and Istv{\'a}n T Altorjay and Nir Dotan and K{\'a}roly Palatka and Ildiko Foldi and Judit Tumpek and Sándor Sipka and Mikl{\'o}s L Udvardy and Tam{\'a}s Dinya and L{\'a}szl{\'o} Lakatos and {\'A}gota Kov{\'a}cs and Tam{\'a}s Moln{\'a}r and Zsolt Tulassay and P{\'a}l Miheller and Gary L. Norman and Tam{\'a}s Szamosi and J{\'a}nos Papp and Peter Laszlo Lakatos},
  journal={The American Journal of Gastroenterology},
  year={2008},
  volume={103},
  pages={665-681}
}
BACKGROUND:Antibodies to Saccharomyces cerevisiae (S. cerevisiae) (ASCA) and porin protein-C of Escherichia coli (anti-OmpC) are associated with disease phenotype and may be of diagnostic importance in inflammatory bowel diseases (IBD). Our aim was to determine whether a panel of new antibodies against bacterial proteins and carbohydrates could help differentiate among the various forms of IBD, and whether they were associated with particular clinical manifestations in a Hungarian cohort of IBD… 
Pancreatic Autoantibodies Are Associated with Reactivity to Microbial Antibodies, Penetrating Disease Behavior, Perianal Disease, and Extraintestinal Manifestations, But Not with NOD2/CARD15 or TLR4 Genotype in a Hungarian IBD Cohort
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PAB autoantibodies in combination with ASCA or anti‐glycan antibodies increase the sensitivity for detecting Crohn's disease, especially isolated colonic CD.
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TLDR
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There is currently insufficient evidence to recommend the use of antibody testing to predict responses to treatment or surgery in patients with IBD, but the combined presence and magnitude of a large panel of antibodies appear to be of value in predicting disease progression.
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  • Medicine, Biology
    Postgraduate medicine
  • 2010
TLDR
Serologic panels of multiple IBD biomarkers can be used to identify the relative risk of progression to complicated disease behaviors, and that this information may ultimately impact therapeutic decisions.
Characteristics of Inflammatory Bowel Disease Serology in Patients With Indeterminate Colitis
TLDR
The disease phenotype in the majority of individuals initially labeled with IC evolved to be more consistent with either UC or CD on follow-up, suggesting pANCA, ASCA, and anti-OmpC, individually, were of limited utility in predicting a patient's subsequent disease phenotype.
Utility of serological markers in inflammatory bowel diseases: gadget or magic?
TLDR
An increasing number of observations confirms that patients with Crohn's disease expressing multiple serologic markers at high titers are more likely to have complicated small bowel disease and are at higher risk for surgery than those without, or with low titers of antibodies.
Serologic Anti-GP2 Antibodies Are Associated with Genetic Polymorphisms, Fibrostenosis, and Need for Surgical Resection in Crohn's Disease
TLDR
Anti-GP2 antibodies may aid as a tool for diagnosis and differentiation of CD and could indicate a more complicated CD course.
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TLDR
Serological markers were useful in the differentiation between CD and UC in an Eastern European IBD cohort, and Reactivity to microbial components was associated with disease phenotype and NOD2/CARD15 genotype, further supporting the role of altered microbial sensing in the pathogenesis of CD.
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Utility of serological markers in inflammatory bowel diseases: gadget or magic?
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An increasing number of observations confirms that patients with Crohn's disease expressing multiple serologic markers at high titers are more likely to have complicated small bowel disease and are at higher risk for surgery than those without, or with low titers of antibodies.
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