New NO-donors with antithrombotic and vasodilating activities, part 15 nitrolic acids.

Abstract

Five 1-oximino-1-nitro compounds (nitrolic acids) were prepared and tested for antithrombotic and blood pressure lowering activities. 1-Nitro-ethanone 1-oxime (1, ethylnitrolic acid) 2 h after oral administration to rats inhibited thrombus formation by a laser beam in mesenteric arterioles of rats by 69% and by 46% in venules (60 mg/kg). The blood pressure of SHR rats even at this high dose only was decreased by 10% suggesting that antithrombotic and blood pressure effects can be dissociated. The in vitro decomposition of 1 at 37 degrees C nearly exclusively gave N2O and acetic acid indicating that HNO primarily had been formed.

Cite this paper

@article{Rehse1996NewNW, title={New NO-donors with antithrombotic and vasodilating activities, part 15 nitrolic acids.}, author={Klaus Rehse and M Herpel and Dariusz Piechocki}, journal={Archiv der Pharmazie}, year={1996}, volume={329 2}, pages={83-6} }