New Molecular and Cellular Mechanisms of Tolerance: Tolerogenic Actions of IL-2.

@article{Prol2016NewMA,
  title={New Molecular and Cellular Mechanisms of Tolerance: Tolerogenic Actions of IL-2.},
  author={Louis P{\'e}rol and Eliane Piaggio},
  journal={Methods in molecular biology},
  year={2016},
  volume={1371},
  pages={
          11-28
        }
}
Interleukin-2 (IL-2) is an old molecule with brand new functions. Indeed, IL-2 has been first described as a T-cell growth factor but recent data pointed out that its main function in vivo is the maintenance of immune tolerance. Mechanistically, IL-2 is essential for the development and function of CD4(+) Foxp3(+) regulatory T cells (Treg cells) that are essential players in the control of immune responded to self, tumors, microbes and grafts. Treg cells are exquisitely sensitive to IL-2 due to… CONTINUE READING
1
Twitter Mention