New Microbicidal Functions of Tracheal Glands: Defective Anti-Infectious Response to Pseudomonas aeruginosa in Cystic Fibrosis

@article{Bastonero2009NewMF,
  title={New Microbicidal Functions of Tracheal Glands: Defective Anti-Infectious Response to Pseudomonas aeruginosa in Cystic Fibrosis},
  author={Sonia Bastonero and Yannick Le Priol and Martine Armand and Christophe S{\'e}bastien Bernard and Martine Reynaud-Gaubert and Daniel Olive and Daniel Parzy and Sophie de Bentzmann and Christian Capo and J. L. M{\`e}ge},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={194 - 222}
}
  • Sonia Bastonero, Yannick Le Priol, +7 authors J. L. Mège
  • Published in PloS one 2009
  • Medicine, Biology
  • Tracheal glands (TG) may play a specific role in the pathogenesis of cystic fibrosis (CF), a disease due to mutations in the cftr gene and characterized by airway inflammation and Pseudomonas aeruginosa infection. We compared the gene expression of wild-type TG cells and TG cells with the cftr DeltaF508 mutation (CF-TG cells) using microarrays covering the whole human genome. In the absence of infection, CF-TG cells constitutively exhibited an inflammatory signature, including genes that encode… CONTINUE READING

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