New Methods in Cardiovascular Biology Noise-Free Visualization of Microscopic Calcium Signaling by Pixel-Wise Fitting

Abstract

Rationale: Our insights into physiological and pathophysiological cardiac excitation-contraction coupling has greatly benefited from significant advancement in optical technologies such as high-speed confocal microscopy. This has pushed pixel dwell times into the time domain of nanoseconds, resulting in low signal-to-noise ratios, which have limited data… (More)

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6 Figures and Tables