New Locus for Autosomal Dominant Mitral Valve Prolapse on Chromosome 13: Clinical Insights From Genetic Studies

@article{Nesta2005NewLF,
  title={New Locus for Autosomal Dominant Mitral Valve Prolapse on Chromosome 13: Clinical Insights From Genetic Studies},
  author={Francesca Nesta and Maire Leyne and Chaim Yosefy and Charles Simpson and Daisy Dai and Jane E. Marshall and Judy W Hung and Susan A. Slaugenhaupt and Robert A. Levine},
  journal={Circulation},
  year={2005},
  volume={112},
  pages={2022-2030}
}
Background—Mitral valve prolapse (MVP) is a common disorder associated with mitral regurgitation, endocarditis, heart failure, and sudden death. To date, 2 MVP loci have been described, but the defective genes have yet to be discovered. In the present study, we analyzed a large family segregating MVP, and identified a new locus, MMVP3. This study and others have enabled us to explore mitral valve morphological variations of currently uncertain clinical significance. Methods and Results… 

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The current knowledge of the diagnosis, epidemiology, prognosis, and genetic mechanisms underlying the pathogenesis and progression of mitral valve prolapse are summarized.
...

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