New Lipophilic Terbutaline Ester Prodrugs with Long Effect Duration

Abstract

Two new lipophilic terbutaline ester prodrugs – the biscarbamate bambuterol (pINN) and the cascade ester D 2438 – have been designed with the goal to achieve enhanced absorption and high hydrolytic stability during first-pass in order to prolong the effect duration of the parent compound. Bambuterol, the bis-N,N-dimethyl-carbamate of terbutaline, displays… (More)
DOI: 10.1023/A:1016322524471

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Cite this paper

@article{Olsson1984NewLT, title={New Lipophilic Terbutaline Ester Prodrugs with Long Effect Duration}, author={Ola Olsson and Leif-{\AA}. Svensson}, journal={Pharmaceutical Research}, year={1984}, volume={1}, pages={19-23} }