New Lignans from Antidesma hainanensis Inhibit NO Production in BV2 Microglial Cells.

Abstract

Two new lignans (7S,7'R,8S,8'R)-3,3'-dimethoxy-7,7'-epoxylignan-4,4',9-triol 4-O-β-D-glucopyranoside (1) and 9-O-formylaviculin (2) together with other thirteen known secondary metabolites were isolated from the leaves of Antidesma hainanensis. Their chemical structures were determined using NMR, electrospray ionization (ESI)-MS, circular dichroism (CD) spectroscopic methods, and as well as by comparison with those reported in the literature. Neuro-inflammatory activity of isolated compounds was evaluated by their inhibition on nitric oxide (NO) production in activated BV2 microglial cells. At concentration of 40 µM, compounds 1-3, 5, 7, 8, 9, 14, and 15 exhibited inhibitory effects over 50%, suggesting that they could be potential candidate drugs for the cure of neuro-inflammation. In addition, compounds 1, 8, 14, and 15 significantly inhibited 16.23, 27.76, 21.23, and 29.44% NO production at diluted concentration as low as 2.5 µM.

Cite this paper

@article{Kiem2016NewLF, title={New Lignans from Antidesma hainanensis Inhibit NO Production in BV2 Microglial Cells.}, author={Phan Van Kiem and Le Canh Viet Cuong and Bui Huu Tai and Nguyen Xuan Nhiem and Hoang Anh and Tran Hong Quang and Nguyen Thi Thanh Ngan and Hyuncheol Oh and Youn Chul Kim}, journal={Chemical & pharmaceutical bulletin}, year={2016}, volume={64 12}, pages={1707-1712} }