New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes.

@article{Reddy2009NewLD,
  title={New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes.},
  author={P Prabhakar Reddy and Ashok Tiwari and R Ranga Rao and Kuncha Madhusudhana and V Rama Subba Rao and Amtul Zehra Ali and Katragadda Suresh Babu and Janaswamy Madhusudana Rao},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 9},
  pages={2562-5}
}
Phytochemical investigation of antihyperglycemic extract of rhizomes of Hedychium spicatum led to the isolation of two new labdane type diterpenes 2, 3 along with seven known compounds (1, 4-9). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The new compound 2 displayed strong intestinal alpha-glucosidase inhibitory activity. Other compounds also displayed varying degree of intestinal alpha-glucosidase inhibitory potential.