New Kipukasin from Marine Isolate of the Fungus Aspergillus flavus

@article{Zhuravleva2016NewKF,
  title={New Kipukasin from Marine Isolate of the Fungus Aspergillus flavus},
  author={Olesya I. Zhuravleva and Natalia N. Kirichuk and Vladimir Denisenko and Pavel S. Dmitrenok and Mikhael V. Pivkin and Sh. Sh. Afiyatullov},
  journal={Chemistry of Natural Compounds},
  year={2016},
  volume={52},
  pages={266-268}
}
A new aromatic nucleoside kipukasin J (1) and two known compounds decumbenone B (2) and cyclopenol (3) were separated from marine isolate of the fungus Aspergillus flavus. The structure of kipukasin J was elucidated using NMR spectroscopy and high-resolution mass spectrometry. The antimicrobial activity of the separated compounds was investigated. 

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References

SHOWING 1-10 OF 10 REFERENCES
Nucleoside derivatives from the marine-derived fungus Aspergillusversicolor
Four nucleoside derivatives (1–4) were isolated from the fungus Aspergillus versicolor derived from the gorgonian Dichotella gemmacea collected in the South China Sea. Their structures were
Kipukasins, nucleoside derivatives from Aspergillus versicolor.
TLDR
Seven new aroyl uridine derivatives (kipukasins A-G; 1-7) were isolated from solid-substrate fermentation cultures of two different Hawaiian isolates of Aspergillus versicolor, showing modest activity in assays against Gram-positive bacteria.
Antimicrobial aflatoxins from the marine-derived fungus Aspergillus flavus 092008
TLDR
Results showed that hydration and hydrogenation of 8-double bond significantly reduces the cytotoxicity of aflatoxins, while the esterification at C-8 increases the cytOToxicity.
Flavusides A and B, antibacterial cerebrosides from the marine-derived fungus Aspergillus flavus.
TLDR
Flavusides A and B and two new antibacterial cerebroside derivatives have been isolated from the extract of a marine isolate of the fungus Aspergillus flavus and the structure and absolute stereochemistry of two cerebrosides were assigned on the basis of NMR and Tandem FAB-MS/MS experiments.
PTP1B inhibitory secondary metabolites from marine-derived fungal strains Penicillium spp. and Eurotium sp.
TLDR
The kinetic analysis of PTP1B inhibition by compounds 1 and 5 suggested that compound 1 inhibited P TP1B activity in a noncompetitive manner, whereas compound 5 inhibited PTP2BActivity in a competitive manner.
New Angucyclines and Antimicrobial Diketopiperazines from the Marine Mollusk-Derived Actinomycete Saccharothrix espanaensis An 113
TLDR
Two new angucyclines, saccharothrixmicines A and B, together with three known diketopiperazines 4-6 were isolated from the actinomycete SaccharOTHrix espanaensis An 113 associated with the marine mollusk Anadara broughtoni and exhibited activity towards Candida albicans and Xanthomonas sp.
Indole Diterpenoids and Isocoumarin from the Fungus, Aspergillus flavus, Isolated from the Prawn, Penaeus vannamei
TLDR
Two new indole-diterpenoids (1 and 2) and a new isocoumarin (3) were isolated from the fermentation broth of the marine-derived fungus, Aspergillus flavus OUCMDZ-2205 and the absolute configurations of the known compounds, 4–6 and leporin A (6a), were also determined for the first time.
Steroids and an oxylipin from an algicolous isolate of Aspergillus flavus
TLDR
Two new oxylipins isolated from the cultures of Aspergillus flavus exhibited low activity to inhibit acetylcholinesterase and no activity against plant pathogenic fungi Colletotrichum lagenarium and Fusarium oxysporum.
Discovery of novel secondary metabolites from fungi—is it really a random walk through a random forest?
TLDR
Twenty-nine Nodulisporium strains isolated from material obtained worldwide were found to produce secondary metabolites as measured by HPLC, and within the set of cultures that produced the mean or greater than the mean number of metabolites, were found all of the producers of rarer metabolites.