New Intravenous Anaesthetics and Neuromuscular Blocking Drugs

  title={New Intravenous Anaesthetics and Neuromuscular Blocking Drugs},
  author={Charles S. Reilly and Walter S. Nimmo},
SummaryThe newer neuromuscular blocking drugs include vecuronium and atracurium. Vecuronium is a competitive neuromuscular blocking drug with a steroid nucleus. A dose of 0.1 mg/kg has an onset time of 2 minutes and provides surgical paralysis for 20 minutes. Recovery to 90% twitch height occurs in 40 to 50 minutes. Vecuronium has few adverse effects and its use is associated with cardiovascular stability. Atracurium is a competitive neuromuscular blocking drug which undergoes Hofmann… 
Effect of dexmedetomidine with or without butorphanol on the clinico-physiological and haemodynamic stability in dogs undergoing ovariohysterectomy in midazolam and ketamine anaesthesia
Addition of butorphanol did not have significant effects on the clinico-physiological and haemodynamic stability; however, it reduced the amount of ketamine required for maintenance and better sedation.
Safety of intravenous and inhalation anesthetics
Determination of Minimal Alveolar Anesthetic Concentration (MAC) and Safety Margin of Inhalation Anesthetics are determined.
Full-Cost Determination of Different Levels of Care in the Intensive Care Unit
The analysis revealed a marked increase in patient-minute cost associated with mechanical ventilation, which has important economic implications with respect to selection of an appropriate neuromuscular blocking agent.


The neuromuscular blocking action of ORG NC 45, a new pancuronium derivative, in anaesthetized patients. A pilot study.
Org NC 45 appears to be approximately as potent as pancuronium, but has a more rapid onset of action, considerably shorter duration of action and faster recovery rate than Pancuronium and represents a potentially valuable addition to the armamentarium of clinically useful muscle relaxants.
Verapamil and reversal of vecuronium neuromuscular blockade.
The present case report deals with the prolonged effect of vecuronium bromide in a patient with renal insufficiency treated for supraventricular tachycardia with the calcium entry blocker verapamil.
Evaluation of atracurium in anaesthetized man.
The course of action of atracurium was appreciably shorter than that of other recognized competitive blocking agents and provided adequate relaxation during surgical intervention for 15--45 min; spontaneous recovery without the use of neostigmine was observed in some patients.
Neuromuscular blocking effects of vecuronium and pancuronium during halothane anaesthesia.
The neuromuscular blocking properties of vecuronium (Org NC 45) and pancuronium were compared in 40 patients during halothane anaesthesia. Onset time was found to be dose-dependent, but no
Clinical Pharmacology of Atracurium Besylate (BW 33A): A New Non‐depolarizing Muscle Relaxant
Atracurium spontaneously decomposes at physiologic pH via the Hofmann elimination reaction and may also undergo ester hydrolysis independent of plasma cholinesterase, which may explain the lack of cumulative effect and the drug's intermediate duration of action.
Clinical comparison of atracurium and vecuronium (Org NC 45).
Both vecuronium and atracurium would appear to have certain advantages over existing non-depolarizing neuromuscular blocking drugs.
Evaluation of cumulative properties of three new nondepolarizing neuromuscular blocking drugs BW A444U, atracurium and vecuronium.
Comparative patterns of recovery during successive doses of three new, relatively non-cumulative, intermediate-duration non-depolarizing neuromuscular blocking drugs, BW A444U, atracurium and vecuronium, were studied in 94 surgical patients and suggest that the cumulative properties of the new drugs may be ranked as follows.
Neuromuscular Effects of Atracurium in Man
The neuromuscular effects of atracurium were studied in class I or II patients anesthetized by a N2O-O2narcotic technique and the block could be antagonized by the common clinical combination of atropine and neostigmine.
Atracurium for intubation in man
Atracurium may be a suitable alternative to suxamethonium when speed of intubation is not critical, and conditions were excellent in 80% of patients 1 minute after suxmethonia.
Antagonism of profound neuromuscular blockade induced by vecuronium or atracurium. Comparison of neostigmine with edrophonium.
The results show that profound neuromuscular blockade cannot be rapidly antagonized by either of these two agents, but if reversal is required under these circumstances, neostigmine would be the more effective drug.