New Insights of Ustilago maydis as Yeast Model for Genetic and Biotechnological Research: A Review

  title={New Insights of Ustilago maydis as Yeast Model for Genetic and Biotechnological Research: A Review},
  author={D. R. Olic{\'o}n-Hern{\'a}ndez and M. Araiza-Villanueva and J. P. Pardo and E. Aranda and Guadalupe Guerra-S{\'a}nchez},
  journal={Current Microbiology},
The basidiomycete Ustilago maydis is a biotrophic organism responsible for corn smut disease. In recent years, it has become one of the most promising models for biochemical and biotechnological research due to advantages, such as rapid growth, and easy genetic manipulation. In some aspects, this yeast is more similar to complex eukaryotes, such as humans, compared to standard laboratory yeast models. U. maydis can be employed as a tool to explore physiological processes with more versatility… Expand
An Optimized Ustilago maydis for Itaconic Acid Production at Maximal Theoretical Yield
Itaconate production was further optimized by consolidating different optimizations into one strain, which resulted in itaconic acid production at theoretical maximal yield, which was achieved under biotechnologically relevant fed-batch fermentations with continuous feed. Expand
"When worlds collide and smuts converge": Tales from the 1st International Ustilago/Smut Convergence".
The overall goals of the meeting were to expand the smut model systems being used and to expand participation by the next generations of scientists with these fungi, with a combination of emphasis on student and post-doc presentations, mentoring of such individuals, and active recruitment of participation by groups under-represented at such meetings in recent years in the US. Expand


Ustilago maydis, model system for analysis of the molecular basis of fungal pathogenicity.
This review highlights recent insights into molecular mechanisms of complex signalling pathways that are involved in the transition from budding to filamentous growth and operate during the pathogenic growth phase of U. maydis development. Expand
Ustilago maydis as a Pathogen.
This review describes the most prominent features of the U. maydis-maize pathosystem as well as genes and pathways most relevant to disease and highlights recent developments that place this system at the forefront of understanding the function of secreted effectors in eukaryotic pathogens. Expand
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
The discovery of the secreted protein gene clusters and the functional demonstration of their decisive role in the infection process illuminate previously unknown mechanisms of pathogenicity operating in biotrophic fungi. Expand
Establishment of compatibility in the Ustilago maydis/maize pathosystem.
It is considered it unlikely that U. maydis feeds on carbohydrates derived from the digestion of plant cell wall material, but uses its set of plant CWDEs for softening the cell wall structure as a prerequisite for in planta growth. Expand
Ustilago maydis, a new fungal model system for cell biology.
The corn smut fungus Ustilago maydis is introduced as a new model organism for studying cell biological processes and growing evidence suggests that basic principles of long-distance transport, mitosis and motor-based microtubule organization are conserved between U. maydis and humans. Expand
Pathocycles: Ustilago maydis as a model to study the relationships between cell cycle and virulence in pathogenic fungi
The aim of this review is to summarize recent advances in the unveiling of cell cycle regulation in U. maydis and discuss the connection between cell cycle and virulence and how cell cycle control is an important downstream target in the fungus-plant interaction. Expand
Ustilago maydis secondary metabolism-from genomics to biochemistry.
The pathways for the production of extracellular glycolipids that serve as biosurfactants, iron-chelating siderophores, tryptophan-derived indole pigments and indole acetic acid are reviewed, the elucidation of which has greatly profited from the availability of the U. maydis genome sequence. Expand
Genetic and biochemical insights into the itaconate pathway of Ustilago maydis enable enhanced production.
The titer, rate and yield of itaconate produced by U. maydis was considerably increased, thus contributing to the industrial application of this unicellular fungus for the biotechnological production of this valuable biomass derived chemical. Expand
Transcriptomic analysis of the dimorphic transition of Ustilago maydis induced in vitro by a change in pH.
This work examined the transcriptome during the dimorphic transition of the basidiomycota phytopathogenic fungus Ustilago maydis using microarrays, utilizing yeast and mycelium monomorphic mutants as controls to identify 154 genes of the fungus that are specifically involved in the dimmorphic transition induced by a pH change. Expand
Analysis of a polygalacturonase gene of Ustilago maydis and characterization of the encoded enzyme
Structural models of PGU1 based on homologous enzymes yielded a typical right‐handed β‐helix fold of pectinolytic enzymes classified in the glycosyl hydrolases family 28, and the U. maydis PGU 1 is related with endo rather than exo polygalacturonases. Expand