Neuro-Bio-Behavioral Mechanisms of Placebo and Nocebo Responses: Implications for Clinical Trials and Clinical Practice
- Psychology, MedicinePharmacological Reviews
The neuro-bio-behavioral mechanisms underlying placebo and nocebo responses that are currently known in terms of different diseases and physiologic systems are summarized and critically examined.
The placebo response: neurobiological and clinical issues of neurological relevance.
- Psychology, MedicineProgress in brain research
Nature of the placebo and nocebo effect in relation to functional neurologic disorders.
- Psychology, BiologyHandbook of clinical neurology
Mechanisms and therapeutic implications of the placebo effect in neurological and psychiatric conditions.
- Psychology, MedicinePharmacology & therapeutics
Placebo analgesia and beyond: a melting pot of concepts and ideas for neuroscience
- PsychologyCurrent opinion in anaesthesiology
Recent evidence confirms and extends previous findings on the key role of prefrontal regions in the placebo response, and represents an excellent tool for neuroscience in the experimental setting.
Placebo-related effects: a meta-narrative review of conceptualization, mechanisms and their relevance in rheumatology.
Using a meta-narrative approach, this review of conceptualizations, determinants, mechanisms and models of placebo effects shows that placebo effects are genuine biopsychosocial phenomena strongly affected by context and factors surrounding the patient and treatments.
Placebo and nocebo effects in the neurological practice.
- Psychology, MedicineArquivos de neuro-psiquiatria
The objective of this review is to distinguish specific from non-specific effects, so that the presence of positive effects in the group that received placebo (placebo effect) and the absence of adverse effects inThe group receiving placebo (nocebo effect), lead to confounding in interpreting the results.
SHOWING 1-10 OF 181 REFERENCES
Mechanisms of placebo and placebo-related effects across diseases and treatments.
- Psychology, Medicine
Recent research has revealed that these psychosocial-induced biochemical changes in a patient's brain and body in turn may affect the course of a disease and the response to a therapy.
A comprehensive review of the placebo effect: recent advances and current thought.
- Psychology, MedicineAnnual review of psychology
The demonstration of the involvement of placebo mechanisms inclinical trials and routine clinical practice has highlighted interesting considerations for clinical trial design and opened up opportunities for ethical enhancement of these mechanisms in clinical practice.
Expectations and associations that heal: Immunomodulatory placebo effects and its neurobiology
- Psychology, BiologyBrain, Behavior, and Immunity
Neurophysiology and psychobiology of the placebo response
- Psychology, MedicineCurrent opinion in psychiatry
Novel findings will allow better planning of clinical drug trials, better handling of clinical trial data in the future, and finally, may eventually result in improved patient management.
Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses.
- Psychology, MedicineArchives of general psychiatry
Placebo and nocebo effects are associated with opposite responses of DA and endogenous opioid neurotransmission in a distributed network of regions and form part of the circuit typically implicated in reward responses and motivated behavior.
Experimental designs and brain mapping approaches for studying the placebo analgesic effect
- Medicine, PsychologyEuropean Journal of Applied Physiology
This work systematically reviews the literature that deals with placebo analgesia, emphasizing both the methodological aspects and the neurobiological advances.
[Can the placebo be the cure?].
- MedicineWiadomosci lekarskie
The short history of placebos is reviewed and a series of examples of the effects are given and a more rigorous approach to their understanding is given.
Understanding the Placebo Effect: Contributions from Neuroimaging
- Psychology, MedicineMolecular Imaging and Biology
Evidence from positron emission tomography and functional magnetic resonance imaging studies suggests that expectations of symptom improvement are driven by frontal cortical areas, particularly the dorsolateral prefrontal, orbitofrontal, and anterior cingulate cortices.
Revelation of a personal placebo response: Its effects on mood, attitudes and future placebo responding
- Psychology, MedicinePAIN