New Insights into the Placebo and Nocebo Responses

  title={New Insights into the Placebo and Nocebo Responses},
  author={P. Enck and F. Benedetti and M. Schedlowski},
  • P. Enck, F. Benedetti, M. Schedlowski
  • Published 2008
  • Psychology, Medicine
  • Neuron
  • In modern medicine, the placebo response or placebo effect has often been regarded as a nuisance in basic research and particularly in clinical research. The latest scientific evidence has demonstrated, however, that the placebo effect and the nocebo effect, the negative effects of placebo, stem from highly active processes in the brain that are mediated by psychological mechanisms such as expectation and conditioning. These processes have been described in some detail for many diseases and… CONTINUE READING
    469 Citations

    Figures and Topics from this paper.

    The placebo response: neurobiological and clinical issues of neurological relevance.
    • 48
    The placebo effect: From concepts to genes
    • 133
    Nature of the placebo and nocebo effect in relation to functional neurologic disorders.
    • 13
    Placebo analgesia and beyond: a melting pot of concepts and ideas for neuroscience
    • 29
    • PDF
    Mechanisms and therapeutic implications of the placebo effect in neurological and psychiatric conditions.
    • 44
    • Highly Influenced
    Nocebo and lessebo effects.
    • 1
    Placebo and nocebo effects in the neurological practice.
    • 9
    • PDF


    Mechanisms of placebo and placebo-related effects across diseases and treatments.
    • 281
    A comprehensive review of the placebo effect: recent advances and current thought.
    • 877
    • PDF
    Expectations and associations that heal: Immunomodulatory placebo effects and its neurobiology
    • 150
    Neurophysiology and psychobiology of the placebo response
    • 30
    • PDF
    Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses.
    • 506
    • Highly Influential
    • PDF
    Experimental designs and brain mapping approaches for studying the placebo analgesic effect
    • 41
    [Can the placebo be the cure?].
    • 17
    Understanding the Placebo Effect: Contributions from Neuroimaging
    • 76
    • PDF
    Placebos and painkillers: is mind as real as matter?
    • 395
    • PDF