New Insights into the Mechanisms of Action of Cotinine and its Distinctive Effects from Nicotine

@article{Grizzell2014NewII,
  title={New Insights into the Mechanisms of Action of Cotinine and its Distinctive Effects from Nicotine},
  author={J. Grizzell and V. Echeverr{\'i}a},
  journal={Neurochemical Research},
  year={2014},
  volume={40},
  pages={2032-2046}
}
Abstract Tobacco consumption is far higher among a number of psychiatric and neurological diseases, supporting the notion that some component(s) of tobacco may underlie the oft-reported reduction in associated symptoms during tobacco use. Popular dogma holds that this component is nicotine. However, increasing evidence support theories that cotinine, the main metabolite of nicotine, may underlie at least some of nicotine’s actions in the nervous system, apart from its adverse cardiovascular and… Expand
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