New Insights into How Yersinia pestis Adapts to Its Mammalian Host during Bubonic Plague

@article{Pradel2014NewII,
  title={New Insights into How Yersinia pestis Adapts to Its Mammalian Host during Bubonic Plague},
  author={E. Pradel and N. Lemaître and Maud Merchez and I. Ricard and A. Reboul and Am{\'e}lie Dewitte and F. Sebbane},
  journal={PLoS Pathogens},
  year={2014},
  volume={10}
}
Bubonic plague (a fatal, flea-transmitted disease) remains an international public health concern. Although our understanding of the pathogenesis of bubonic plague has improved significantly over the last few decades, researchers have still not been able to define the complete set of Y. pestis genes needed for disease or to characterize the mechanisms that enable infection. Here, we generated a library of Y. pestis mutants, each lacking one or more of the genes previously identified as being up… Expand
Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination and diagnostics.
TLDR
Recent research advances on Y. pestis evolution, virulence factors function, bacterial strategies to subvert mammalian innate immune responses, vaccination and problems associated to pneumonic plague diagnosis are reviewed. Expand
Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics
TLDR
Recent research advances on Y. pestis evolution, virulence factor function, bacterial strategies to subvert mammalian innate immune responses, vaccination, and problems associated with pneumonic plague diagnosis are reviewed. Expand
Plague and the Defeat of Mammalian Innate Immunity: Systematic Genetic Analysis of Yersinia pestis Virulence Factors: A Dissertation
TLDR
Evidence that Y. pestis has evolved specific mechanisms to interfere with platelet activation, likely in order to evade immune responses and promote maintenance of bacteremia by undermining platelet thrombotic and innate immune functions is presented. Expand
A refined model of how Yersinia pestis produces a transmissible infection in its flea vector
TLDR
The present results highlight the physiopathological and molecular mechanisms leading to flea blockage, show that the role of a gene like rpiA changes in space and in time during an infection, and emphasize that evolution is a gradual process punctuated by sudden jumps. Expand
Interplay between Yersinia pestis and its flea vector in lipoate metabolism
TLDR
Using Yersinia pestis and its flea vector, a bioluminescence-based approach is developed and employed to investigate the mechanisms of pathogenesis at an unprecedented level of detail, finding lipoylation of metabolic enzymes, via the biosynthesis and salvage of lipoate, increases the Y. pestis transmission rate by fleas. Expand
High-throughput analysis of Yersinia pseudotuberculosis gene essentiality in optimised in vitro conditions, and implications for the speciation of Yersinia pestis
TLDR
It is found that the two species uniquely rely upon different iron acquisition and respiratory metabolic pathways under similar in vitro conditions, and the shared essential genes represent ideal candidates for the development of novel antimicrobials against both species. Expand
Inactivation of Peroxiredoxin 6 by the Pla Protease of Yersinia pestis
TLDR
A proteomic screen to identify host proteins contained within the bronchoalveolar lavage fluid of mice that are cleaved and/or processed by Y. pestis in a Pla-dependent manner identified peroxiredoxin 6 (Prdx6), a host factor that contributes to pulmonary surfactant metabolism and lung defense against oxidative stress, as a previously unknown substrate of Pla. Expand
Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae
TLDR
Food availability has an impact on expression of virulence genes in response to C-sources, demonstrating a tight link between the pathogenicity of yersiniae and utilization of nutrients. Expand
Genome-Wide Mutant Fitness Profiling Identifies Nutritional Requirements for Optimal Growth of Yersinia pestis in Deep Tissue
TLDR
It is suggested that diverse nutrient limitations in deep tissue play a more important role in controlling bacterial infection than has heretofore been appreciated. Expand
Perspectives on Yersinia pestis: A Model for Studying Zoonotic Pathogens.
TLDR
Its unique lifestyle makes Y. pestis an ideal model for studying host-vector-environment-pathogen interactions and repeated pandemics and local outbreaks provide clues about the infectious disease outbreaks that have occurred in human history. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 66 REFERENCES
The Dependence of the Yersinia pestis Capsule on Pathogenesis Is Influenced by the Mouse Background
TLDR
It is reported that Y. pestis requires, in a nonredundant manner, both PsaA and Caf1 to achieve its full pathogenic ability in both pneumonic and bubonic plague in C57BL/6J mice, and this observation that the degree of requirement for Caf1 is dependent on the mouse background indicates that the virulence of Yersinia pestis isdependent on the genetic makeup of its host. Expand
Adaptive response of Yersinia pestis to extracellular effectors of innate immunity during bubonic plague.
TLDR
The ability of Y. pestis to destroy immune cells and remain extracellular in the bubo appears to limit exposure to some but not all innate immune effectors. Expand
Role of the Yersinia pestis Ail Protein in Preventing a Protective Polymorphonuclear Leukocyte Response during Bubonic Plague
TLDR
Systemic spread and mortality were greatly attenuated, however, and a productive adaptive immune response was generated after high-dose challenge, as evidenced by high serum antibody levels against Y. pestis F1 antigen. Expand
Transit through the Flea Vector Induces a Pretransmission Innate Immunity Resistance Phenotype in Yersinia pestis
TLDR
It is suggested that transit through the flea vector induces a phenotype that enhances survival and dissemination of Y. pestis after transmission to the mammalian host. Expand
The Yersinia pestis caf1M1A1 Fimbrial Capsule Operon Promotes Transmission by Flea Bite in a Mouse Model of Bubonic Plague
TLDR
The results suggest that acquisition of the caf locus via horizontal transfer by an ancestral Y. pestis strain increased transmissibility and the potential for epidemic spread and support a model in which atypical caf-negative strains could emerge during climatic conditions that favor a high flea burden. Expand
Poor vector competence of fleas and the evolution of hypervirulence in Yersinia pestis.
TLDR
It is shown that the infectivity of Y. pestis to its most proficient vector, the rat flea Xenopsylla cheopis, and subsequent transmission efficiency are both low, suggesting that the rapidly fatal gram-negative sepsis that typifies plague is a consequence of the high threshold bacteremia level that must be attained to complete the transmission cycle. Expand
Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity.
TLDR
DNA microarray technology was used to analyze the transcriptional responses of the bacteria during interaction with the mouse lung, validating the use of this technology to identify loci essential to the virulence of Y. pestis. Expand
Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis.
TLDR
Analysis of the population genetic structure of Y. pestis and the two other pathogenic Yersinia species shows consistent with previous inferences that Antiqua caused a plague pandemic in the sixth century, Medievalis caused the Black Death and subsequent epidemics during the second pandemic wave, and Orientalis cause the current Plague pandemic. Expand
Transcriptomic and Innate Immune Responses to Yersinia pestis in the Lymph Node during Bubonic Plague
TLDR
The ability to counteract a PMN response in the lymph node appears to be a major in vivo function of the Y. pestis virulence plasmid, according to lymph node histopathology and transcriptome levels. Expand
Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis.
  • P. Chain, É. Carniel, +20 authors E. García
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
The complete genomic sequence of Y. pseudotuberculosis IP32953 is reported and provides a sobering example of how a highly virulent epidemic clone can suddenly emerge from a less virulent, closely related progenitor. Expand
...
1
2
3
4
5
...