New Insights in Oxidant Biology in Asthma.

  title={New Insights in Oxidant Biology in Asthma.},
  author={Serpil C. Erzurum},
  journal={Annals of the American Thoracic Society},
  volume={13 Suppl 1},
Research over the past 30 years has identified mechanistic biochemical oxidation pathways that contribute to asthma pathophysiology. Redox imbalance is present in asthma and strongly linked to the pathobiology of airflow obstruction, airway hyperreactivity, and remodeling. High levels of reactive oxygen species, reactive nitrogen species, and oxidatively modified proteins in the lung, blood, and urine provide conclusive evidence for pathologic oxidation in asthma. Concurrent loss of… CONTINUE READING

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