New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes

@article{Bender2020NewII,
  title={New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes},
  author={Christine Bender and S. Rajendran and M. V. von Herrath},
  journal={Frontiers in Endocrinology},
  year={2020},
  volume={11}
}
Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing “dogmas”, mostly derived from studies of animal models and sometimes limited human samples, have to be revised now. For example, we have learned that autoreactive CD8 T cells are present even in healthy individuals within the exocrine pancreas. Furthermore, their “attraction” to islets probably relies… Expand

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